True or False: Silver sulfadiazine accelerates epithelialization in deep partial-thickness burns.

• A. True
• B. False
• C. It accelerates epithelialization only in superficial burns
• D. It has no effect on epithelialization

Answer: (B)

Epithelialization in burn wounds depends on keratinocyte migration from the wound edges and from adnexal structures in the dermis. An agent that is cytotoxic to these cells can slow healing even while it fights infection. Silver sulfadiazine provides broad antimicrobial coverage, but it can be toxic to keratinocytes and fibroblasts, which can delay reepithelialization. In deep partial-thickness burns, where healing relies on epidermal growth from remaining skin appendages, applying silver sulfadiazine is more likely to hinder epithelialization than accelerate it.

So the statement is false: silver sulfadiazine does not accelerate epithelialization in deep partial-thickness burns. It may help with infection control, but its cytotoxic effects on key healing cells can slow the healing process. In practice, management often emphasizes removing nonviable tissue and considering grafting for deeper burns, with dressings or topical options chosen to support and not impede epithelialization.